Ferroptosis: a potential treatment scheme for glioblastoma
10.3760/cma.j.cn115355-20220727-00483
- VernacularTitle:铁死亡：胶质母细胞瘤治疗的潜在方案
- Author:
Pengfei LI
1
;
Hongming JI
;
Shiyuan ZHANG
;
Changchen HU
Author Information
1. 山西医科大学第五临床医学院，太原 030012
- Keywords:
Ferroptosis;
Glioblastoma;
Cell death;
Targeted therapy
- From:
Cancer Research and Clinic
2023;35(8):634-637
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma (GBM) is a clinically common type of glioma with a very poor prognosis and complex drug resistance mechanisms, high mortality, short survival time; invasiveness and recurrence are the main obstacles to treatment. Ferroptosis is an iron-dependent regulated cell death associated with massive lipid peroxidation that is related with the development and treatment response of various types of tumors. Cancer cells rely on their strong antioxidant capacity to avoid ferroptosis, therefore, exploring ferroptosis may be an effective strategy to prevent tumor proliferation and invasion. This article mainly reviews the mechanism of ferroptosis in GBM, as well as the research status and progress of ferroptosis as a potential therapeutic target.
