Progress of therapeutic efficacy and predictive indicators of neoadjuvant chemoradiotherapy for locally advanced rectal cancer
10.3760/cma.j.cn115355-20221125-00742
- VernacularTitle:新辅助放化疗治疗局部进展期直肠癌效果及预测指标研究进展
- Author:
Zhongyuan BAI
1
;
Xinxuan ZHAO
;
Jun XU
Author Information
1. 山西医科大学第一临床医学院，太原 030001
- Keywords:
Rectal neoplasms;
Neoadjuvant therapy;
Forecasting;
Treatment outcome
- From:
Cancer Research and Clinic
2023;35(5):397-400
- CountryChina
- Language:Chinese
-
Abstract:
The standard treatment for locally advanced rectal cancer is neoadjuvant chemoradiotherapy(nCRT) followed by surgery. The therapeutic efficacy of patients after nCRT differs greatly. Effective use of nCRT can accurately predict the efficacy and help patients avoid damage caused by excessive treatment. This article describes the main methods of current nCRT and newly proposed concepts, such as totally neoadjuvant therapy, summarzies its impact on the efficacy of locally advanced rectal cancer, introduces the potential predictive biomarkers of efficacy evaluation for nCRT and the latest advances in clinical, histological and molecular predictors, and discusses the potential value of efficacy prediction in nCRT .
