Progress of adipokines in cancer treatment
10.3760/cma.j.cn115355-20220616-00370
- VernacularTitle:脂肪因子在肿瘤治疗中的研究进展
- Author:
Yuqin ZANG
1
;
Ruqian ZHAO
;
Shiqi LIU
;
Yingmei WANG
;
Fengxia XUE
Author Information
1. 天津医科大学总医院妇产科，天津 300052
- Keywords:
Obesity;
Neoplasms;
Adipokines;
Molecular targeted therapy;
Research
- From:
Cancer Research and Clinic
2023;35(5):389-393
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is a well-known high-risk factor for many kinds of neoplasms. Adipokines secreted by adipose tissue play an important role in the process of obesity promoting tumorigenesis and development, and different adipokines play a role in promoting or suppressing cancer via different signaling pathways. Currently, lifestyle modification to control weight and targeted therapy of adipokines and their receptors are major research directions of cancer treatment, but most of the studies are still in the stage of basic and pre-clinical research. Therefore, the molecular mechanisms of adipokines in promoting or suppressing cancer should be further explored, and the dual inhibitors as well as combined therapy are the key research strategies for adipokines in cancer treatment in the future.
