Progress of expression and function of messenger RNA CCT6A in malignancies
10.3760/cma.j.cn115355-20220418-00237
- VernacularTitle:信使RNA CCT6A在恶性肿瘤中的表达及作用研究进展
- Author:
Junhu LI
1
;
Hanzheng ZHAO
;
Jiayong YU
;
Yuenan HUANG
Author Information
1. 哈尔滨医科大学附属第二医院普通外科十病区，哈尔滨 150086
- Keywords:
Neoplasm;
CCT6A;
RNA, messenger;
Tumor microenvironment
- From:
Cancer Research and Clinic
2023;35(5):386-389
- CountryChina
- Language:Chinese
-
Abstract:
Messenger RNA(mRNA) CCT6A can encode chaperone proteins and plays an important role in malignant tumors such as colorectal cancer, lung cancer and breast cancer. CCT6A is highly expressed in malignant tumors, which can be used as a biomarker to assess patients' prognosis, and promote malignant biological behaviors such as tumor proliferation and metastasis by regulating transforming growth factor β signals, cell cycles, and other pathways. CCT6A can also modulate immune cell infiltration in the tumor microenvironment and may be a potential target for tumor immunotherapy. The paper reviews the expression and function of CCT6A in malignancies.
