Correlation of immune inflammatory index with occurrence, development and prognosis of hepatocellular carcinoma
10.3760/cma.j.cn115355-20220110-00015
- VernacularTitle:免疫炎性细胞与肝癌发生、发展及预后的关系
- Author:
Mingzheng LI
1
;
Yan WANG
;
Shiming WANG
Author Information
1. 山西医科大学，太原 030001
- Keywords:
Immunotherapy;
Carcinoma, hepatocellular;
Immune checkpoint inhibitors;
Inflammation;
Cytokines;
Prognosis
- From:
Cancer Research and Clinic
2023;35(3):236-240
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is a typical chronic inflammatory-associated malignancy. Chronic inflammation continuously damages the reticuloendothelial system of the liver and leads to impairment of immune surveillance, which in turn leads to dysregulation of the immune environment. Immune escape caused by impaired surveillance system can improve the immunogenicity of tumor, which plays an important role in the occurrence and development of tumors. Studies have shown that the indicators including immune inflammatory cells such as neutrophils, platelets and lymphocytes can predict the prognosis of hepatocellular carcinoma, the individualized treatment and early intervention for patients on this basis is expected to improve the prognosis of patients. The article introduces the role of immune cells in the occurrence and development of hepatocellular carcinoma, and summarizes the relationship between peripheral blood immune inflammatory indicators and prognosis of hepatocellular carcinoma.
