Progress of methyltransferase-like 3 in breast cancer
10.3760/cma.j.cn115355-20220220-00096
- VernacularTitle:甲基化转移酶3在乳腺癌中的研究进展
- Author:
Jia ZHU
1
;
Jinxu WEN
;
Jiayi ZHANG
;
Yuexin WANG
Author Information
1. 华北理工大学研究生学院，唐山 060000
- Keywords:
Breast neoplasms;
m6A methylation;
RNA methyltransferases
- From:
Cancer Research and Clinic
2023;35(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
Methyltransferase-like 3 (METTL3), as the most important methylase of N6-methyladenine (m6A),plays an important role in the development and progression of breast cancer by influencing various regulatory mechanisms, such as methylation level, mRNA stability of cancer-related genes, oncogene expression and cancer cell signaling pathways. This paper reviews the regulatory mechanism of METTL3 in breast cancer and summarizes the latest research progress of METTL3 in the development and progression of breast cancer.
