Effects of combined acupuncture and medication on hyperarousal state and serum copeptin in patients with chronic insomnia
10.1007/s11726-023-1386-0
- VernacularTitle:针药并用对慢性失眠症患者过度觉醒状态及血清和肽素的影响
- Author:
Yue CAO
;
Sha HU
;
Cheng CHEN
;
Jun WANG
;
Zhaoan YU
;
Hongliang LI
;
Feng ZHONG
;
Fuqing ZHANG
- Keywords:
Acupuncture Therapy;
Acupuncture Medication Combined;
Sleep Disorders;
Insomnia;
Sleep Quality;
Pittsburgh Sleep Quality Index;
Copeptin
- From:
Journal of Acupuncture and Tuina Science
2023;21(4):279-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of combined acupuncture and medication on hyperarousal state and serum copeptin(CPT)in patients with chronic insomnia(CI),and to explore its possible mechanism of action.Methods:A total of 70 CI patients meeting the inclusion criteria were divided into an observation group and a control group by the random number table method,with 35 cases in each group.The control group was given estazolam tablets before bedtime,1 mg/time,once a day.The observation group was treated with additional Yi Nao An Shen acupuncture therapy(acupuncture for benefiting the brain and tranquillization)on the basis of the medication treatment,4 times a week.After 4 weeks of treatment,the Pittsburgh sleep quality index(PSQI)score,insomnia severity index(ISI)score,pre-sleep arousal scale(PSAS)score,hyperarousal scale(HAS)score,and the change in serum CPT level were compared between the two groups.Results:During the study,there were 2 dropout cases in the observation group and 1 dropout case in the control group.After treatment,the PSQI,ISI,PSAS,and HAS scores and the serum CPT level in both groups decreased compared with the same group before treatment,and the intra-group differences were statistically significant(P<0.05).After treatment,changes in each above scale score and the serum CPT level in the observation group were much more significant and were statistically different from those in the control group(P<0.05).Conclusion:Acupuncture plus medication can improve sleep quality,reduce the degree of insomnia,and regulate hyperarousal state in patients with CI,and its mechanism of action may be related to the down-regulation of serum CPT level.
