Expression of c-MET in Invasive Meningioma.
- Author:
Sumi YUN
1
;
Jae Moon KOH
;
Kyu Sang LEE
;
An Na SEO
;
Kyung Han NAM
;
Gheeyoung CHOE
Author Information
- Publication Type:Original Article
- Keywords: Meningioma; Proto-oncogene proteins c-MET; Hepatocyte growth factor; Neoplasm invasiveness; Immunohistochemistry
- MeSH: Brain; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Meningioma*; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met; Recurrence
- From:Journal of Pathology and Translational Medicine 2015;49(1):44-51
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have been reported to be involved in cancer invasion. METHODS: We examined the immunohistochemical expression of c-MET and HGF in 100 cases of patients with meningiomas who have undergone complete tumor removal. RESULTS: c-MET(-High) and HGF(-High) were found in 17% and 13% of meningiomas, respectively. Brain invasion was observed in 17.6% of c-MET(-High) meningiomas, but in only 2.4% of c-MET(-Low) meningiomas (p=.033). Bone/soft tissue invasion was observed in 23.5% of c-MET(-High) meningiomas and in 9.6% of c-MET(-Low) meningiomas (p=.119). HGF(-High) did not show statistical association with brain invasion or bone/soft tissue invasion. c-MET(-High) demonstrated shorter recurrence-free survival (RFS, 93.5+/-8.2 months vs 96.1+/-1.9 months); however, this difference was not statistically significant (p=.139). There was no association of HGF(-High) with RFS. CONCLUSIONS: This study demonstrates that c-MET(-High) is associated with brain invasion of meningiomas, and that c-MET expression may be a useful predictive marker for meningioma recurrence. Patients with invasive meningiomas with high expressions of c-MET may be good candidates for targeted therapy using c-MET inhibitors.
