Improvement of xeroderma and water content of the stratum corneum in children with a moisturizer containing oat kernel oil
10.3760/cma.j.issn.1671-0290.2023.03.013
- VernacularTitle:含燕麦仁油的舒缓护理霜改善儿童干皮症及角质层含水量的研究
- Author:
Suhua WU
1
;
Kefei ZHOU
;
Ming LI
;
Jingxin JIANG
;
Yizhen ZHANG
;
Yan LI
;
Linfeng LI
Author Information
1. 首都医科大学附属北京友谊医院皮肤性病科，北京 100050
- Keywords:
Xeroderma;
Dry skin;
Oat kernel oil;
Moisturizer;
Children
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2023;29(3):218-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the influence of a moisturizer containing oat kernel oil for xeroderma and water content of the stratum corneum in children.Methods:From September to December 2022, 30 children with xeroderma were treated in the Dermatology Department of Tongzhou Maternal and Child Health Hospital of Beijing; 13 were males and 17 were females, and the age was 7.33±2.63 years. This was a single-center self-controlled trial. All children applied the moisturizer on the dry skin of the bilateral limbs two time per day for 14 days, and were followed up at 7 days and 14 days. Efficacy was evaluated according to the water content of the stratum corneum, visual scale, xerosis severity scale (XSS), Specified Symptom Sum Score (SRRC), Visual Analog Scale (VAS) and so on. and side-reactions were recorded.Results:After application of the moisturizer, the median of water content in the stratum corneum was 49.00 (33.83, 87.25), 48.84 (32.58, 100.34) at 7 d and 14 d respectively, showing significant increases compared with that at baseline (median 26.51 (16.00, 47.75) ( Z=-3.075, Z=-2.911, P<0.01). The visual scale, XSS, SRRC and VAS showed that compared with the baseline at 7 d, 14 d, the skin dryness and pruritus scores improved significantly ( Z=-4.424, -4.150, -3.943, -4.400; Z=-4.744, -4.409, -4.260, -4.409, P<0.01). Conclusions:The application of this moisturizer containing oat kernel oil could effectively improve skin dryness and the water content of the stratum corneum without serious adverse reactions.
