Clinical effects of nanoneedle injection of compound betamethasone combined with 308 nm excimer laser on patients with stable vitiligo
10.3760/cma.j.issn.1671-0290.2022.06.002
- VernacularTitle:纳米微针导入复方倍他米松联合308 nm准分子激光治疗稳定期白癜风的效果
- Author:
Yaping TANG
1
;
Zhenjie LI
;
Weiyu LIU
;
Shujuan ZHANG
;
Yangqi LI
;
Yumei LIU
;
Huilan ZHU
Author Information
1. 广州市皮肤病医院皮肤科，广州 510095
- Keywords:
Vitiligo;
Nanoneedle;
Compound betamethasone injection;
308 nm excimer laser
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2022;28(6):454-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy for nanoscale microneedle injection of compound betamethasone combined with 308 nm excimer laser in the treatment of stable vitiligo patients.Methods:A total of 80 patients with stable vitiligo were enrolled in Guangzhou Dermatology Hospital from May 2018 to May 2020. There were 40 patients (21 males and 19 females) in control group, aged 17-65 (32.4±1.7) years, and 40 patients (20 males and 20 females) in observation group, aged 18-67 (28.7±1.8) years. The control group was treated with compound betamethasone injection packet combined with 308 nm excimer laser. The observation group was treated with nanoneedle injection of compound betamethasone combined with 308 nm excimer laser. We compared the clinical efficacy and incidence of adverse reactions between the two groups.Results:Comparison of clinical efficacy showed that after 3 months of treatment, the total effective rates of the observation group and the control group were 80.00% and 67.50%, respectively, with significant difference (χ 2=4.560, P<0.05). After 3 months of treatment, the white spot area of the control group was (9.89±1.65) cm 2, which was significantly higher than that of the observation group (7.83±1.78) cm 2 ( t=5.370, P<0.05). Conclusions:The nanoneedle injection of compound betamethasone combined with 308 nm excimer laser in the treatment of stable vitiligo is effective and safe.
