Therapeutic effect of compound acid, alpha hydroxyl acid and salicylic acid on acne vulgaris: a comparative study
10.3760/cma.j.issn.1671-0290.2022.06.001
- VernacularTitle:复合酸、果酸、水杨酸治疗轻中度痤疮的疗效比较研究
- Author:
Lijuan WU
1
;
Yun WEI
;
Yumiao FENG
;
Lan SUN
;
Wenyan ZHU
Author Information
1. 南京医科大学附属苏州医院苏州市立医院皮肤科，苏州 215000
- Keywords:
Acne vulgaris;
Comparative effectiveness research;
Compound acid;
Alpha hydroxyl acid;
Salicylic acid
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2022;28(6):449-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the curative effect and adverse reactions of compound acid, alpha hydroxyl acid (AHA), and salicylic acid (SA) in the treatment of mild to moderate acne.Methods:A total of 105 patients admitted in Suzhou Municipal Hospital from August 2019 to May 2020 were divided into three groups randomly and treated with compound acid, AHA and SA, once every 3 weeks, 4 times totally. The efficacy was evaluated before treatment, 3 weeks after 1 time, 2 times, 3 times, and 4 times. The number of non-inflammatory lesions (comedos) and inflammatory lesions (papules or pustules) were recorded. VISIA image was used to record the patient＇s facial characteristics before treatment and 3 weeks after 4 times. The occurrence of adverse reactions was recorded.Results:Three groups were all safe and effective. The efficiency of non-inflammatory lesions showed that there was no statistically significant difference between the 3 groups (χ 2= 4.58, P=0.101). The effective rate of inflammatory lesions in the compound acid and SA groups were higher than that of AHA group, and the difference was statistically significant (χ 2=6.45, P=0.040). After 4 times, the clinical data of purpurin, red area, and spot in compound acid and SA groups were higher than those before treatment, and the difference was statistically significant ( P<0.05). While in the AHA group, the purple matter was higher than that before treatment after 4 times, the difference was statistically significant ( t=3.506, P=0.010), and the change in the red area was not statistically significant ( P>0.05). Conclusions:The compound acid is safe and effective in treating mild and moderate acne. It is effective for acne inflammatory and non-inflammatory lesions. It has less adverse reactions and is worthy of clinical application.
