Necessity and methodological progress on the establishment of continuous reference intervals for pediatric age-dependent indicators
10.3760/cma.j.cn114452-20230524-00257
- VernacularTitle:针对儿童年龄依赖指标建立连续参考区间的必要性及方法学进展
- Author:
Ruohua YAN
1
;
Xiaoxia PENG
;
Yaguang PENG
;
Kun LI
;
Xin NI
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院临床流行病学与循证医学中心，北京 100045
- Keywords:
Child;
Reference interval;
Non-parametric method;
Semi-parametric method
- From:
Chinese Journal of Laboratory Medicine
2023;46(8):872-878
- CountryChina
- Language:Chinese
-
Abstract:
Accurate and applicable reference intervals can provide important information for disease diagnosis, efficacy evaluation, and health monitoring. Age-dependent trends exist for many clinical laboratory indicators, and the interpretation of such indicators should consider the effect of age carefully. However, age-specific reference intervals have certain limitations in clinical application. Continuous reference intervals can not only help accurate interpretation of laboratory test results, but also provide a baseline value for dynamic monitoring of their changing trends. Based on the researches on pediatric reference intervals from our team, this paper introduces different algorithms for establishing continuous reference intervals, and their applicable conditions and implementation steps. The aim of this paper is to provide methodological guidance for the establishment of continuous reference intervals, so as to improve the quality of laboratory reports and the accuracy of clinical diagnosis in China.
