Opportunities and challenges in the clinical application of proteomics
10.3760/cma.j.cn114452-20230220-00101
- VernacularTitle:质谱蛋白质组学在临床应用中的机遇和挑战
- Author:
P. Putuma GQAMANA
1
;
L. Brandy YOUNG
;
Y. Victoria ZHANG
Author Information
1. 罗切斯特大学医学中心，病理学和检验医学，罗切斯特，美国
- Keywords:
Mass spectrometry;
Laboratory developed tests;
Proteomics;
Challenge
- From:
Chinese Journal of Laboratory Medicine
2023;46(8):775-779
- CountryChina
- Language:Chinese
-
Abstract:
As a supplement to immunoassay, mass spectrometry plays an important role in clinical laboratory. With the application and development of mass spectrometry technology in proteomics research, clinical laboratory gradually expanded the analyses of small molecules to proteins/peptides, such as thyroglobulin, insulin-like growth factor-Ⅰ, apolipoprotein E and amyloid protein, etc. However, it faces challenges such as long time and high cost of pretreatment optimization, lack of reference materials and imperfect supervision. Although emerging proteomic biomarkers have been slow to translate into clinical diagnosis, the large proteomic database provides a favorable support for future development.
