Research update on DNA methylation in peripheral blood cells as a risk factor for coronary heart disease
10.3760/cma.j.cn114452-20230507-00233
- VernacularTitle:外周血细胞DNA甲基化作为冠心病危险因素的研究进展
- Author:
Shuyang SHENG
1
;
Fang ZHENG
;
Xiaokang ZHANG
;
Fan WANG
;
Boyu LI
;
Daoxi QI
;
Siwei LI
;
Xueping QIU
Author Information
1. 武汉大学中南医院检验科/临床基因诊断中心，武汉 430071
- Keywords:
DNA methylation;
Coronary atherosclerotic heart disease;
Peripheral blood cells;
Marker
- From:
Chinese Journal of Laboratory Medicine
2023;46(7):754-760
- CountryChina
- Language:Chinese
-
Abstract:
Coronary heart disease (CHD) is a kind of cardiovascular diseases originated from atherosclerosis (AS), and chronic inflammation is one of the pathological characteristics. The peripheral blood leukocytes, especially mononuclear cells, play an important role in the AS processes. Recently, in a series of Epigenome-Wide Association Studies (EWAS), multiple DNA differential methylation sites in peripheral blood cells were found to be statistically associated with CHD, which suggested that these DNA differential methylation sites might serve as new risk factors for CHD. The recognition of the variant of DNA methylation as a common epigenetic nucleic acid modification in the occurrence and development of CHD, is ongoing. DNA methylation has the potential to become warning biomarkers, which might provide new ideas and evidences for mechanistic studies of CHD.
