Analysis of lipoprotein(a) level and related factors in healthy Tajik and Kazak adults in Xinjiang
10.3760/cma.j.cn114452-20230206-00074
- VernacularTitle:新疆塔吉克族、哈萨克族健康成年人脂蛋白（a）水平及相关因素分析
- Author:
Menglong JIN
1
;
Mawusumu MAMUTE
;
Hebali SHAPAERMAIMAITI
;
Jianxin LI
;
Jie CAO
;
Fanhua MENG
;
Qian ZHAO
;
Huayin LI
;
Hongyu JI
;
Jialin ABUZHALIHAN
;
Abuduhalike AIGAIXI
;
Xiangfeng LU
;
Zhenyan FU
Author Information
1. 新疆医科大学第一附属医院心脏中心 新疆医科大学省部共建中亚高发病成因与防治国家重点实验室，乌鲁木齐830000
- Keywords:
Cardiovascular diseases;
Lipoprotein(a);
Tajik;
Related factors
- From:
Chinese Journal of Laboratory Medicine
2023;46(7):697-704
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution and related factors of lipoprotein(a) [Lp(a)] level in healthy Tajik and Kazak adults in China.Methods:A cross-sectional study was conducted from May to October 2021 and March to June 2022, and blood samples were collected from 2, 637 healthy Tajik adults [1 010 men, average age: (40.08±14.74) years; 1 627 women, average age: (38.27±12.90) years] in Tashkurgan Tajik Autonomous County and 1 911 healthy Kazak adults [720 men, average age: (42.10±12.26) years; 1 191 women, average age: (38.27±12.90) years] in Fuyun County of Xinjiang. Fasting blood glucose (FBG), creatinine (Cr), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and Lp(a) were measured. The distribution of Lp(a) levels in different sex and age groups was compared. The Lp(a) level of Tajik and Kazakh ethnic groups was compared by Mann-Whitney U test, and correlation factors of Lp(a) level were analyzed by multiple logistic regression. Results:The distribution of Lp(a) level in Tajik and Kazak population was skewed. Lp(a) levels of Tajik and Kazak ranged from the lowest 0.40 mg/L and 0.62 mg/L to the highest 1 229.40 mg/L and 2 108.58 mg/L, respectively, and the median Lp(a) level was 78.90 (38.60, 190.20) mg/L and 103.30 (49.57, 234.27) mg/L, respectively. Median Lp(a) level of Kazak was significantly higher than that of Tjik ( P<0.001). The median Lp(a) levels of Tajik males and females were similar: 77.45 (39.80, 187.10) mg/L and 79.90 (38.60, 192.30) mg/L ( P=0.948). The median Lp(a) levels of Kazakh males and females were also similar: 109.42 (50.49, 230.38) mg/L and 99.01 (49.11, 237.25) mg/L, respectively ( P=0.578). After pooling the data of Tajik and Kazak and adjusting for age, sex, BMI, smoking, drinking, blood pressure, blood glucose and other factors, Lp(a) level was correlated with ethnic (standard partial regression coefficient 0.066, P=0.008) and LDL-C level (standard partial regression coefficient 0.136, P<0.001). Conclusions:Lp(a) level in healthy Tajik and Kazak adults varied greatly among individuals, and Kazak residents had a higher Lp(a) level than Tajik residents. There was no significant sex difference in Lp(a) level among Tajik and Kazakh, and LDL-C and ethnicity are independent factors related to Lp(a) level.
