Application of aptamers in the detection of key inflammatory cytokines
10.3760/cma.j.cn114452-20230418-00200
- VernacularTitle:核酸适配体在炎症关键细胞因子检测中的应用
- Author:
Huimin NIU
1
;
Xueke LIU
;
Xi ZHOU
;
Shengxing ZHANG
Author Information
1. 联勤保障部队第九〇〇医院 福建省适配体技术重点实验室，福州350025
- Keywords:
Biosensing techniques;
Cytokines;
Inflammation
- From:
Chinese Journal of Laboratory Medicine
2023;46(6):641-647
- CountryChina
- Language:Chinese
-
Abstract:
Pro-inflammatory cytokines selectively induce specific signals to regulate host responses. Since the immunological imbalance caused by abnormal release of cytokines is involved in the development of many diseases, cytokine-specific detections are of great clinical significance for disease diagnosis and efficacy monitoring. Aptamers are single-stranded nucleic acid sequences which can bind to the target with high selectivity and affinity. It has attracted much attention in the development of novel aptamers-based methods for the detection of specific biomarkers of inflammatory diseases. This paper reviewed recent advances in electrochemical and optical aptasensors for the detection of tumor necrosis factor-α, interleukin-6, transforming growth factor-β, interferon-γ and interleukin-8. The findings offered valuable insights into the clinical application potential and challenges of nucleic acid aptamers in the detection of key inflammatory cytokines, providing a meaningful reference for the development of aptamer-based cytokines sensitive detection point-of-care testing equipment and novel diagnostic strategies for inflammatory disorders.
