Advances in researches of polymyxin resistance mechanism in Klebsiella pneumoniae
10.3760/cma.j.cn114452-20230110-00015
- VernacularTitle:肺炎克雷伯菌多黏菌素耐药机制的研究进展
- Author:
Yongli WU
1
;
Binghuai LU
Author Information
1. 中日友好医院 中国医学科学院 北京协和医学院研究生院中日友好医院，北京 100029
- Keywords:
Polymyxins;
Klebsiella pneumoniae;
Drug resistance, bacterial
- From:
Chinese Journal of Laboratory Medicine
2023;46(6):628-633
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the carbapenem-resistant Klebsiella pneumoniae (CRKP) continues to significantly threaten public health. The limited therapeutic options are increasingly challenging for clinicians to reintroduce the polymyxin as last-resort drug, with the results that polymyxin resistance is not scarce in settings. The polymyxin resistance mechanism is diversified, mainly the modification of the lipopolysaccharide (LPS). In addition to phoPQ, pmrAB, crrAB and mgrB on chromosome, plasmid-carried mcr gene have been found to mediate the LPS modification. The mgrB gene variation plays an important role in polymyxin resistance. Above all, the aim of the current review is to discuss the mechanism of polymyxin resistance mechanism in Klebsiella pneumoniae provide insights for preventing this phenomenon.
