Clinical value of nucleic acid detection for hepatitis B virus screening in hospitalized patients
- VernacularTitle:核酸检测在入院患者乙型肝炎病毒筛查中的应用
- Author:
Chunhong DU
1
;
Junhua HU
;
Yuan ZHANG
;
Jiwu GONG
;
Jun ZHOU
;
Qin MENG
;
Juan LIU
;
Jiangcun YANG
;
Rong GUI
;
Xianping LYU
;
Rong XIA
;
Fenghua LIU
;
Li QIN
;
Shu SU
;
Jinqi MA
;
Juan CAI
;
Huifang JIN
;
Qi ZHANG
;
Jun ZHANG
;
Rongyi CAO
;
Xiying LI
;
Peng WANG
Author Information
- Keywords: Hepatitis B Virus; Nucleic acid amplification techniques; DNA; Hepatitis B surface antigens
- From: Chinese Journal of Laboratory Medicine 2023;46(1):27-31
- CountryChina
- Language:Chinese
- Abstract: Objective:To explore clinical value of nucleic acid detection for hepatitis B virus (HBV) screening in hospitalized patients.Methods:This cross-sectional study collected and analyzed plasma samples from patients admitted to 10 domestic medical institutions from July 2021 to December 2021. Serological immunoassay and nucleic acid screening were used to simultaneously detect hepatitis B markers such as hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B e Antigen (HBeAg), hepatitis B e antibody (HBeAb), hepatitis B core antibody (HBcAb),and HBV DNA. Statistical analysis was performed on the serology, nucleic acid test results and clinical information of the patients.Results:Of the 8 655 collected samples, HBsAg was positive in 216 (2.50%) samples,HBV DNA was positive in 238 (2.75%) samples ( P>0.05); 210 (2.43%) samples were positive for both HBsAg and HBV DNA, 28 (0.32%) were HBsAg negative and HBV DNA positive, 6 cases (0.07%) were HBsAg positive and HBV DNA negative. Conclusion:These results indicate that the HBV DNA testing is equally effective as hepatitis B virus serological detection for hepatitis B virus screening in hospitalized patients.
