Clinical value of highly sensitive hepatitis B virus surface antigen and DNA assays
10.3760/cma.j.cn114452-20220817-00475
- VernacularTitle:高灵敏乙型肝炎病毒表面抗原和DNA检测的临床应用价值
- Author:
Bo FENG
1
;
Jiarui ZHENG
;
Zilong WANG
Author Information
1. 北京大学人民医院 北京大学肝病研究所 丙型肝炎和肝病免疫治疗北京市重点实验室，北京 100044
- Keywords:
Hepatitis B;
Hepatitis B surface antigen;
DNA;
Nucleic acid amplification techniques
- From:
Chinese Journal of Laboratory Medicine
2023;46(1):7-11
- CountryChina
- Language:Chinese
-
Abstract:
For patients with chronic hepatitis B, the indications of antiviral treatment are gradually expanding, and the pursuit of various degrees of cure (partial cure, functional cure and complete cure) is consistently improving, which enhances the urgent clinical need for improving the detection sensitivity of hepatitis B virus (HBV) surface antigen and DNA. Based on the availability of commercial highly sensitive hepatitis B surface antigen and HBV DNA detection reagents, we summarized their applications in the diagnosis of HBV infection, their role on guiding selection of antiviral treatment agents and treatment plans, their prediction efficacy and indication for drug withdrawal, their role on monitoring therapy efficacy and the prediction of disease outcomes. Taken together, highly sensitive hepatitis B virus surface antigen and DNA assays and related detection technology play an important role in the whole management process of chronic HBV infection.
