Research progress on the biological clock genes and diabetic retinopathy
10.3760/cma.j.cn511434-20210710-00371
- VernacularTitle:生物钟基因在糖尿病视网膜病变发病机制中的作用机制研究进展
- Author:
Qi ZHOU
1
;
Fang LU
;
Hejiang YE
Author Information
1. 成都中医药大学眼科学院, 成都 610072
- Keywords:
Diabetic retinopathy;
Diabetes mellitus;
Biological clock genes;
Circadian rhythm
- From:
Chinese Journal of Ocular Fundus Diseases
2023;39(1):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is one of the most common and serious complication of diabetes mellitus, which is the main cause of vision loss in adults. Biological clock genes produce circadian rhythms and control its operation, while the disorder of the expression causes the occurrence and development of a series of diseases. It has been demonstrated that biological clock genes might take effects in the development and progression of DR. On the one hand, circadian rhythm disorder-related behavior disrupts the circadian oscillation of clock genes, and the change in its expression level is prone to unbalanced regulation of glucose metabolism, ultimately increasing the risk of type 2 diabetes mellitus and DR pathogenesis. On the other hand, DR patients exhibit symptoms of circadian rhythm disorders, and it has been suggested that the clock genes may control the development and progression of DR by affecting a variety of retinal pathophysiological processes. Therefore, maintaining normal circadian rhythm can be used as a disease prevention strategy, and studying the molecular mechanism of clock genes in DR can provide new ideas for more comprehensive elaboration of the pathogenesis of DR and search for new therapeutic targets.
