Advances in transsynaptic retrograde degeneration of optic neuropathy
10.3760/cma.j.cn511434-20220930-00517
- VernacularTitle:逆行跨突触变性视神经病变的研究进展
- Author:
Yan HUO
1
;
Xuemei LIN
;
Songdi WU
Author Information
1. 西北大学附属第一医院（西安市第一医院）神经眼科, 西安 710002
- Keywords:
Transsynaptic retrograde degeneration of optic neuropathy;
Retinal ganglion cells;
Visual field defect;
Atrophy of optic tract;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2022;38(12):1035-1038
- CountryChina
- Language:Chinese
-
Abstract:
Transsynaptic retrograde degeneration of optic neuropathy (TRDON) refers to the degeneration and/or apoptosis of presynaptic neurons (retinal ganglion cells) caused by damage to the lateral geniculate body and post-geniculate visual pathway. At present, the pathogenesis of TRDON is secondary apoptosis of P β-type retinal ganglion cells, resulting in the atrophy of optic tract, thinning of the retinal nerve fiber layer and retinal ganglion cell layer thickness and declining of retinal microvascular density, which are consistent with the visual field defect attributed to the primary disease. Of which, the thinning of the retinal ganglion cell layer thickness is considered as the characteristic of TRDON. Now, there is little understanding and related research on TRDON in China. Clinicians should pay attention to the characteristics and severity, occurrence time and location of the above structural changes in these patients through optical coherence tomography, and monitor the activity and progress of the lesions, so as to determine the cut-off point for drug intervention and the drug targets for developing new treatment methods, and bring benefits for patients in partial visual function recovery and disability reduction.
