Functional study of Zinc in regulating M1 polarization of tumor associated macrophages during radical resection of lung cancer
10.3760/cma.j.cn112434-20221113-00351
- VernacularTitle:锌元素调节胸腔镜下肺癌根治术患者肿瘤相关巨噬细胞M1极化的功能研究
- Author:
Wenhui CHEN
1
;
Bo WEI
Author Information
1. 首都医科大学附属北京天坛医院胸外科，北京 100070
- Keywords:
Radical resection of lung cancer;
Inflammatory factor;
Serum zinc content;
Macrophage
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2023;39(6):348-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the molecular mechanism of zinc donor regulating macrophage polarization, and to explore the correlation between serum zinc content and the clinical index during radical resection of lung cancer.Methods:One hundred and thirty-two patients who undergoing radical resection of lung cancer were enrolled in this study. The serum zinc content was detected by atomic absorption spectrophotometry before operation. The patients were allocated into high-Zn group and low-Zn group. The blood samples of the included subjects were collected before operation (before), immediately after operation (POP1) and 6 hours after operation (POP2), and the plasma high-sensitivity C-reactive protein (hs-CRP) and catalase were detected. The correlation between serum zinc content and clinical features were analyzed. Metrological statistics was performed by using t test or Mann- Whitney test, and counting statistics was performed by χ2 test. Results:The POP1-hs-CRP[(1.69±0.66)mg/L vs. (1.99±0.43)mg/L, POP2-hs-CRP[(3.51±1.01)mg/L vs. (4.59±0.78)mg/L] and other indicators of high-Zn group were significantly lower than those of low-Zn group.Conclusion:There is a negative correlation between serum zinc content and the inflammation during radical resection of lung cancer, suggesting that appropriate zinc supplementation has a protective effect on radical resection of lung cancer patients.
