The role and mechanism of pyroptosis in abdominal aortic aneurysm
10.3760/cma.j.cn112434-20220103-00004
- VernacularTitle:细胞焦亡在腹主动脉瘤中的作用及机制
- Author:
Yiwei YAO
1
;
Yuchen CAI
;
Ganyi CHEN
;
Wen CHEN
;
Xin CHEN
Author Information
1. 南京医科大学附属南京医院（南京市第一医院）心胸外科，南京 210006
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2023;39(3):186-192
- CountryChina
- Language:Chinese
-
Abstract:
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with chronic inflammation in the vascular wall while its specific pathogenesis is not fully understood. Recently, a growing number of studies have indicated that pyroptosis, which is a pro-inflammatory kind of programmed cell death might play a vital role in AAA. In this review, we first summarize the role of pyroptosis in AAA progression by not only providing a literature review on the expression changes of NLRP3 inflammasome components and effector mediators in clinical and experimental AAAs, but also discussing the effects of genetic defects or pharmacological inhibition of NLRP3 inflammasome components on experimental AAAs. Next, we introduce the mechanism of canonical and non-canonical pathway of pyroptosis and its activation and execution process. Finally, we discuss several pyroptosis-related drug targets for treating AAA by inhibiting the assembly of NLRP3 inflammasome and its effector mediators. In conclusion, we believe that pyroptosis might be a new treatment target of AAA.
