The expression patterns of SMG family members in aortas of patients with Stanford type A aortic dissection
10.3760/cma.j.cn112434-20211124-00370
- VernacularTitle:Stanford A型主动脉夹层中SMG基因家族的表达研究
- Author:
Zihao ZHANG
1
;
Rui LI
;
Dingsheng JIANG
;
Xin FENG
Author Information
1. 华中科技大学同济医学院附属同济医院心脏大血管外科，武汉 430030
- Keywords:
Aortic dissection;
SMG family;
mRNA NMD
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2023;39(2):88-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the expression patterns of SMG family members and aortic dissection by comparing the expression levels of SMGs in aortic wall of patients with Stanford type A aortic dissection(AD) and normal controls.Methods:The aortic wall samples were collected from 31 normal controls and 65 patients with Stanford type A aortic dissection. The mRNA levels of SMGs in the aortic wall were quantified by RT-PCR, and the correlations between SMGs and aortic diameters of patients with aortic dissection were analyzed.Results:The results of RT-PCR showed that compared with normal aortic wall, the mRNA levels of SMG3(0.642±0.529 vs. 1.126±0.858, P=0.023), SMG6(0.737±0.652 vs. 1.877±1.902, P=0.005), and SMG7(0.624±0.449 vs. 1.339±0.866, P=0.00067) were obviously increased in aortic wall of patients with aortic dissection, while comparable mRNA levels of SMG1, SMG2, SMG4, SMG5, SMG8 and SMG9 were detected between these two groups. In addition, there was no significant correlation between the expression levels of SMG3, SMG6, SMG7 and aortic diameters. Conclusion:The expression levels of SMG3, SMG6 and SMG7mRNA were significantly increased in patients with aortic dissection, suggesting that they may promote the occurrence of aortic dissection, and targeting SMG family members expected to a novel strategy for the prevention and treatment of aortic dissection.
