Association of the RORA Gene Polymorphism and Diurnal Preference in a Young Korean Population.
10.14401/KASMED.2016.23.1.25
- Author:
Hoon JU
1
;
Chul Hyun CHO
;
Joung Ho MOON
;
Leen KIM
;
Heon Jeong LEE
Author Information
1. Department of Medicine, Korea University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Diurnal preference;
Polymorphism;
RORA;
Morningness
- MeSH:
Alleles;
Child;
Child, Orphaned;
Circadian Rhythm;
Genotype;
Humans;
Young Adult
- From:Sleep Medicine and Psychophysiology
2016;23(1):25-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The retinoid-related orphan receptor A (RORA) gene has been reported to have an impact on circadian rhythm regulation. In this study, we analyzed the relationship between the RORA gene polymorphism and diurnal preference in Korean young adults. METHODS: A population of 504 young adults was included in the study. All subjects were given and completed a 13-item composite scale for morningness (CSM). The RORA gene rs11071547 single-nucleotide polymorphism (SNP) was genotyped by PCR-based methods. RESULTS: CSM score was not associated with genotype or allele carrier status of the RORA rs11071547 SNP. CONCLUSION: This result indicates that the RORA rs11071547 SNP does not play a role in diurnal preference.
