Advances in the role of epigenetics in tuberculosis
10.3760/cma.j.cn112309-20230313-00056
- VernacularTitle:表观遗传学在结核病中的研究进展
- Author:
Mengdi PANG
1
;
Xinyu YANG
;
Chuanyou LI
Author Information
1. 北京市疾病预防控制中心结核病实验室，北京 100013
- Keywords:
Tuberculosis;
Epigenetics;
Diagnosis;
DNA methylation;
miRNA
- From:
Chinese Journal of Microbiology and Immunology
2023;43(8):634-641
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis ( Mtb) that seriously endangers human health. Mtb induces epigenetic changes in the host to regulate host genome transcription and immune response, which plays an important role in the growth and replication of Mtb and the development and outcome of TB. Since epigenetic regulation occurs early and is reversible, it has been extensively studied in the pathogenesis of various diseases and has great potential as a molecular target. This paper reviewed the epigenetic changes in host after Mtb infection, including DNA methylation and miRNA, and summarized the role of epigenetics in the pathogenesis of TB and the research progress in potential diagnostic markers.
