Research progress in optimization of therapeutic effect of antibodies against flavivirus
10.3760/cma.j.cn112309-20221208-00402
- VernacularTitle:黄病毒治疗性抗体效应优化的研究进展
- Author:
Xiangjun HAO
1
;
Nan CHEN
;
Lihui CHAI
;
He XIAO
Author Information
1. 军事科学院军事医学研究院毒物药物研究所,北京 100850
- Keywords:
Therapeutic antibody against flaviviruses;
Antibody-dependent enhancement effect
- From:
Chinese Journal of Microbiology and Immunology
2023;43(7):565-569
- CountryChina
- Language:Chinese
-
Abstract:
Flaviviruses are a class of positive-strand RNA viruses mainly transmitted by arthropods, which can cause high mortality and morbidity worldwide. At present, there is no specific therapy. Therapeutic antibodies bring hope for the treatment of flavivirus infection, but the antibody-dependent enhancement (ADE) effect induced by flavivirus infection can lead to disease progression. The ideal therapeutic antibodies against flaviviruses should not only treat flavivirus infection, but also avoid the harm caused by ADE. Therefore, researchers have optimized some of the antibodies to seek the best therapeutic antibodies. This review briefly described the research progress and mechanism of therapeutic antibodies against flaviviruses as well as some strategies to reduce the ADE effect induced by the therapeutic antibodies.