Research progress in the role of E3 ubiquitin ligases in viral infection
10.3760/cma.j.cn112309-20230209-00025
- VernacularTitle:E3泛素连接酶在病毒感染中的作用机制研究进展
- Author:
Lichao ZANG
1
;
Weifeng SHI
Author Information
1. 苏州大学附属第三医院检验科，常州 213003
- Keywords:
E3 ubiquitin ligase;
Viral infection;
Innate immunity
- From:
Chinese Journal of Microbiology and Immunology
2023;43(7):559-564
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitination modifications are a kind of post-translational modifications of proteins widely found in eukaryotes and involved in a variety of biological activities. E3 ubiquitin ligases are an important component of the ubiquitin system, with the function of specific recognition of substrate proteins and mediation of different types of ubiquitination modifications. They can regulate the function and life time of substrate proteins. Recent studies have shown that E3 ubiquitin ligases are widely involved in the regulation of the host innate immune response and can directly or indirectly influence viral infection. Moreover, viruses are able to encode or hijack E3 ubiquitin ligases in their long-term evolution, allowing them to play an important role in viral infection and replication cycle. This paper reviewed the progress in the mechanisms of E3 ubiquitin ligases in innate immune responses and viral infection in recent years.
