Progress in the role of ubiquitin-proteasome system in hepatitis B virus X protein-mediated HBV infection and hepatocarcinogenesis

VernacularTitle:乙型肝炎病毒X蛋白通过泛素-蛋白酶体系统促进乙型肝炎病毒感染和肝癌发生发展的研究进展
Author: Yubo PI ¹ ; Yanmeng CHEN ; Ni TANG
Author Information

1. 重庆医科大学感染性疾病分子生物学教育部重点实验室，重庆　400016
Keywords: Hepatitis B virus; HBx; Hepatocellular carcinoma; Ubiquitin-proteasome system
From: Chinese Journal of Microbiology and Immunology 2023;43(7):517-524
CountryChina
Language:Chinese
Abstract: Chronic hepatitis B virus (HBV) infection is one of the leading causes of hepatocellular carcinoma (HCC). Ubiquitin-proteasome system (UPS) mediates the post-translational modification and degradation of protein in eukaryotic cells. Recent studies have revealed that UPS plays an important role in HBV infection and hepatocarcinogenesis. Targeting HBx to intervene in the progression of HBV infection or HBV-related HCC has become a research hotspot both domestically and internationally in recent years. This article reviewed the progress in HBx promoting HBV infection and hepatocarcinogenesis through UPS.