Research progress in antigenic evolution of influenza A (H3N2) virus
10.3760/cma.j.cn112309-20230317-00064
- VernacularTitle:甲型流感病毒H3N2抗原进化研究进展
- Author:
Mengyi ZHANG
1
;
Lanshu LI
;
Weijin HUANG
;
Chenyan ZHAO
Author Information
1. 中国食品药品检定研究院艾滋病性病病毒疫苗室，北京 102629
- Keywords:
Influenza virus;
H3N2;
Vaccine strain;
Antigenicity;
Predictive model
- From:
Chinese Journal of Microbiology and Immunology
2023;43(6):479-484
- CountryChina
- Language:Chinese
-
Abstract:
Influenza viruses are common pathogens causing respiratory infections in humans. Among the four seasonal influenza viruses, influenza A virus H3N2 has become the leading cause of seasonal influenza illness and death, posing a great threat to public health and the economy. Since it first emerged and caused a pandemic in 1968, H3N2 has been circulating repeatedly in human beings and continually evades host immune attack by antigenic drift, resulting in a decrease in vaccine efficacy. In this paper, the antigenic evolution of influenza A virus H3N2, the impact of antigenic evolution on the selection of vaccine strains and some models for predicting the evolution of influenza viruses were analyzed and reviewed, which paved the road for understanding the antigenic evolution of influenza virus and vaccine development.
