Research progress in plasmacytoid dendritic cells in systemic sclerosis

VernacularTitle:浆细胞样树突状细胞在系统性硬化症中的研究进展
Author: Leting ZHENG ¹ ; Cheng ZHAO
Author Information

1. 广西医科大学第一附属医院风湿免疫科，南宁　530021
Keywords: Plasmacytoid dendritic cells; Interferon; Systemic sclerosis; Fibrosis
From: Chinese Journal of Microbiology and Immunology 2023;43(6):473-478
CountryChina
Language:Chinese
Abstract: Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells that can rapidly produce large amounts of type Ⅰ interferon after activation. They are critical in antiviral immunity and involved in the initiation and development of many autoimmune diseases. Systemic sclerosis (SSc) is an autoimmune disease characterized by immune dysregulation, vasculopathy and progressive fibrosis of the skin and internal organs. Recent studies have found that pDCs are involved in the pathogenesis of SSc. Inhibiting the function of pDCs can effectively prevent inflammation and fibrosis in SSc, highlighting the role of pDCs in the pathogenesis of SSc. Therefore, an in-depth understanding of pDCs and their role in the pathogenesis of SSc is important for the development of pDCs and their mediators as therapeutic targets for SSc.