Progress in the function of nucleoporin 50 and its relationship with viral infection
10.3760/cma.j.cn112309-20221103-00360
- VernacularTitle:人体核孔蛋白50的生物学特性及与病毒感染关系的研究进展
- Author:
Zhanwu LIN
1
;
Kuanhui XIANG
Author Information
1. 北京大学医学部基础医学院病原生物学系和感染病研究中心，北京 100191
- Keywords:
Nucleoporin 50;
Nuclear import;
Regulation of gene expression;
Viral infection;
Hepatitis B virus
- From:
Chinese Journal of Microbiology and Immunology
2023;43(5):389-396
- CountryChina
- Language:Chinese
-
Abstract:
Nucleoporin 50 (Nup50) is a component of nuclear basket in nuclear pore complex. It includes three main domains: N domain binding to importin α, F domain binding to importin β and R domain binding to Ran. The N domain has two importin α-binding segments. There are mainly two models for explaining the role of Nup50 in nuclear import: tri-stable switch and disassemble-recycle model. Nup50 not only participates in nuclear import, but also regulates genome organization and gene expression. In addition, Nup50 is involved in the process of viral infection and replication. There is some evidence that Nup50 is related to hepatitis B virus and human immunodeficiency virus 1 infections. However, there are few researches on the relationship between Nup50 and viral infection. This article summarized the progress in the function of Nup50 and its relationship with viral infection, aiming to provide new ideas for the following in-depth study.
