Role of complement system in the pathogenesis and development of COVID-19
10.3760/cma.j.cn112309-20221117-00380
- VernacularTitle:补体系统在COVID-19发病及进展中的研究进展
- Author:
Wen WANG
1
;
Haijun MA
;
Minghao GUO
Author Information
1. 新乡医学院第一附属医院风湿免疫科,新乡 453100
- Keywords:
SARS-CoV-2;
Pathogenesis;
Complement system;
Targeted therapy
- From:
Chinese Journal of Microbiology and Immunology
2023;43(3):239-242
- CountryChina
- Language:Chinese
-
Abstract:
COVID-19 is a highly contagious disease caused by SARS-CoV-2 infection. Systemic inflammatory response is one of the crucial pathogenic mechanisms. As a key component of the innate immune system, the complement system can quickly provoke an inflammatory reaction against infectious pathogens, serving as a defense mechanism of the body. Studies have showed that the inflammatory storm caused by over-activation of the complement plays a critical role in the development of COVID-19, and blocking or regulating the complement cascade has a certain therapeutic effect on patients with COVID-19. In this review, the roles of the complement system in the pathogenesis and development of COVID-19 were summarized.