Role of complement system in the pathogenesis and development of COVID-19

VernacularTitle:补体系统在COVID-19发病及进展中的研究进展
Author: Wen WANG ¹ ; Haijun MA ; Minghao GUO
Author Information

1. 新乡医学院第一附属医院风湿免疫科，新乡　453100
Keywords: SARS-CoV-2; Pathogenesis; Complement system; Targeted therapy
From: Chinese Journal of Microbiology and Immunology 2023;43(3):239-242
CountryChina
Language:Chinese
Abstract: COVID-19 is a highly contagious disease caused by SARS-CoV-2 infection. Systemic inflammatory response is one of the crucial pathogenic mechanisms. As a key component of the innate immune system, the complement system can quickly provoke an inflammatory reaction against infectious pathogens, serving as a defense mechanism of the body. Studies have showed that the inflammatory storm caused by over-activation of the complement plays a critical role in the development of COVID-19, and blocking or regulating the complement cascade has a certain therapeutic effect on patients with COVID-19. In this review, the roles of the complement system in the pathogenesis and development of COVID-19 were summarized.