Progress in DNA-sensing pathways in Epstein-Barr virus infection
10.3760/cma.j.cn112309-20220907-00287
- VernacularTitle:EB病毒感染中DNA识别通路的研究进展
- Author:
Yifan SUN
1
;
Yang CHENG
;
Fang GONG
;
Yongquan CHEN
;
Xuan HUANG
Author Information
1. 江南大学附属医院检验科，无锡 214122
- Keywords:
Epstein-Barr virus;
DNA-sensing pathway;
Absent in melanoma 2 (AIM2);
Interferon-γ inducible protein 16 (IFI16);
Cyclic GMP-AMP synthase (cGAS);
Stimulator
- From:
Chinese Journal of Microbiology and Immunology
2023;43(2):164-172
- CountryChina
- Language:Chinese
-
Abstract:
Epstein-Barr virus (EBV) is generally susceptible in human beings and multi-organ systems can be involved in EBV infection, such as blood, respiratory, urinary, digestive and nervous systems. EBV infection also plays an important role in the pathogenesis of related tumors, autoimmune diseases and other diseases, posing a great threat to human health. As a DNA virus, EBV can be sensed by DNA recognition receptors to trigger a series of downstream immune responses. A DNA-sensing pathway consists of DNA sensors, adaptor molecules and downstream effector signals. Double-stranded DNA sensors mainly include absent in melanoma 2-like receptors (ALRs) and cyclic GMP-AMP synthase (cGAS). Adaptors were mainly stimulator of interferon genes (STING) and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC). Downstream immune responses mainly involve typeⅠIFN, inflammasomes and proinflammatory cytokines. As a double-stranded DNA virus of the Herpesviridae family, EBV triggers complex innate and adaptive immune responses in the host, especially the sensing pathways mediated by a variety of DNA recognition receptors, which play a key role in host immune defense and pathogen immune evasion. This review made the DNA sensor as the clue to comprehensively summarize the progress in the activation, regulatory mechanism and clinical relevance of DNA-sensing pathways in EBV infection in recent years, aiming to achieve a better understanding of the host innate immune responses during EBV infection and provide an immunological basis for the prevention and treatment of EBV infection-related diseases.
