Role of LC3-associated phagocytosis in regulating infection
10.3760/cma.j.cn112309-20220816-00263
- VernacularTitle:LC3相关吞噬作用调控感染发生发展的研究进展
- Author:
Yu WANG
1
;
Xianhui HUANG
;
Ren SHEN
;
Chaoyang ZHOU
;
Yongliang LOU
;
Danli XIE
Author Information
1. 温州医科大学检验医学院（生命科学学院），温州 325035
- Keywords:
LC3-associated phagocytosis;
Pathogenic microorganisms;
Infection immunity
- From:
Chinese Journal of Microbiology and Immunology
2023;43(2):158-163
- CountryChina
- Language:Chinese
-
Abstract:
LC3-associated phagocytosis (LAP) is a special phagocytosis occurring at the intersection of the two pathways of phagocytosis and autophagy. A hallmark event of the LAP process is the recruitment of microtubule-associated proteinⅠlight chain type 3-Ⅱ(LC3Ⅱ) to the phagosome surface of the monolayer membrane structure. The LAP pathway relies on the functions of the RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein (Rubicon) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. The LC3-associated phagosome (LAPosome) binds to the lysosome to digest and degrade the contents. In recent years, increasing studies have found that LAP plays an important role in the infections caused by pathogenic microorganisms including fungi and bacteria. LAP is a crucial way in the host to resist and degrade the infection of pathogenic microorganisms. However, some pathogenic microorganisms can effectively escape from LAP in the host and even use LAPosome as a place for colonization and replication. This article summarized the recent progress in the role of LAP in host defense against pathogenic microorganism infection and the significance of it in the occurrence and development of diseases.
