Progress in antitumor effect of tumor-associated macrophages in co-culture system
10.3760/cma.j.cn112309-20220801-00254
- VernacularTitle:肿瘤相关巨噬细胞在共培养体系中的免疫抗肿瘤作用研究进展
- Author:
Tiantian CHEN
1
;
Xiaoxiao JIE
;
Wangyu CHEN
;
Yue ZHANG
;
Jie LI
;
Xuliang HAO
Author Information
1. 山西省中医药研究院中药方剂研究所，太原 030012
- Keywords:
Tumor-associated macrophage;
Cell co-culture;
Antitumor immunity
- From:
Chinese Journal of Microbiology and Immunology
2023;43(1):84-89
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are important cells of the immune system. Tumor-associated macrophages are enriched macrophages near tumor cells or tissues. Their role is mainly to promote the construction of tumor inflammatory microenvironment and inhibit tumor immune response. Cell co-culture system is a symbiotic culture system formed by mimicking the internal environment of the body in vitro. The co-culture condition is relatively consistent with the environment in vivo, enabling better information exchange and material exchange between cells, which is a supplement to the monolayer cell culture and animal experiments. Tumor-associated macrophages and tumor cells co-exist in the tumor microenvironment. Thus, constructing a co-culture system for tumor-associated macrophages and tumor cells would be conducive to studying the antitumor effect of tumor-associated macrophages and developing new immunotherapy drugs. The co-culture system would provide a new direction for treating malignant tumors. This article mainly reviewed the co-culture patterns of macrophages and the antitumor effects of different phenotypes of macrophages, and highlighted the importance of using immunotherapy to treat malignant tumors in the tumor microenvironment.
