Immune responses of mucosal-associated invariant T cells in infectious diseases

VernacularTitle:黏膜相关恒定T细胞在感染性疾病中的免疫应答作用
Author: Wenhao MAI ¹ ; Sirui YUAN ; Chaoying ZHOU
Author Information

1. 南方医科大学检验与生物技术学院，广州　510515
Keywords: Mucosal-associated invariant T cells; Infection; Immune responses
From: Chinese Journal of Microbiology and Immunology 2023;43(1):68-75
CountryChina
Language:Chinese
Abstract: Mucosal-associated invariant T (MAIT) cells are highly conserved immune cells that could participate in innate and adaptive immune responses after being activated by major histocompatibility complex class 1-related molecule (MR1) pathway or cytokine pathway. At present, it has been confirmed that a large number of MAIT cells exist in human peripheral blood and specific tissues, and play an important role in infectious diseases. This review focused on the role of MAIT cells in immune responses to different pathogens. Additionally, the therapeutic methods and challenges of targeting MAIT cells in infectious diseases were also discussed.