Role of acetylation modification of host proteins in tuberculosis
10.3760/cma.j.cn112309-20220526-00179
- VernacularTitle:宿主蛋白质乙酰化修饰在结核病发生发展中的作用
- Author:
Yuheng DUAN
1
;
Chuanzhi ZHU
;
Liping PAN
;
Zongde ZHANG
Author Information
1. 首都医科大学附属北京胸科医院，北京市结核病胸部肿瘤研究所，耐药结核病研究北京市重点实验室，分子生物学实验室，北京 101149
- Keywords:
Mycobacterium tuberculosis;
Tuberculosis;
Post-translational modification;
Acetylation
- From:
Chinese Journal of Microbiology and Immunology
2022;42(12):992-996
- CountryChina
- Language:Chinese
-
Abstract:
Post-translational modification of host proteins induced by pathogenic microorganism plays a critical role in the development, treatment and prevention of diseases. Mycobacterium tuberculosis ( Mtb) is an intracellular pathogen that causes tuberculosis. The post-translational modification induced by Mtb infection is essential in the development and progression of tuberculosis. In recent years, it has been found that Mtb-induced host protein acetylation plays an important role in the regulation of host immunity against tuberculosis, which significantly affects the development of tuberculosis. This review focused on the role and mechanism of Mtb in regulating host protein acetylation, aiming to provide reference for future investigation on potential immunotherapy for tuberculosis.
