Role of glycolysis in Th17 cell differentiation in autoimmune diseases
10.3760/cma.j.cn112309-20220607-00193
- VernacularTitle:糖酵解在自身免疫病Th17细胞分化中的作用研究进展
- Author:
Yifan ZHOU
1
;
Baikai MA
;
Hongyu DUAN
;
Hong QI
Author Information
1. 北京大学第三医院眼科，眼部神经损伤的重建保护与康复北京市重点实验室，北京 100191
- Keywords:
Glycolysis;
CD4 + T cells;
Th17 cells;
T cell differentiation;
Autoimmune disease
- From:
Chinese Journal of Microbiology and Immunology
2022;42(12):986-991
- CountryChina
- Language:Chinese
-
Abstract:
T helper 17 (Th17) cells are closely associated with the pathogenesis of several autoimmune and inflammatory diseases, and selective suppression of Th17 cell production and pathogenicity is an effective strategy for the treatment of these diseases. There is growing evidence that cellular metabolism is associated with the development of autoimmune diseases and determines the differentiation and effector functions of Th17 cells, which undergoes a metabolic reorganization during differentiation from an oxidative phosphorylation-based catabolism to a glucose-based anabolic metabolism in the initial T cells. This paper focused on reviewing recent findings regarding the importance of metabolism in T cell differentiation and autoimmune diseases, especially in Th17 cells, and discussing the regulatory mechanisms of glycolysis in Th17 cell differentiation. This review summarized the regulation of metabolism on T-cell activation and differentiation, revealed metabolic targets with specific regulation on Th17 cells, and provided reference for finding potential therapeutic targets for Th17 cell-mediated autoimmune diseases.
