The effects of intermittent theta burst stimulation at different side of the cerebellar hemisphere on swallowing in healthy subjects
10.3760/cma.j.issn.0254-1424.2023.05.005
- VernacularTitle:不同侧小脑半球Theta爆发式经颅磁刺激对健康受试者吞咽调节效应的影响
- Author:
Bingyan WANG
1
;
Pingping MENG
;
Xiaona PAN
;
Hui SUN
;
Qiang WANG
Author Information
1. 青岛大学附属医院康复医学科，青岛 266003
- Keywords:
Swallowing;
Cerebellum;
Theta burst stimulation;
Motor evoked potentials
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2023;45(5):408-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe any stimulatory effect of intermittent theta burst stimulation (iTBS) on the cerebral swallowing cortex and the cerebellar swallowing motor area and to explore the related mechanisms.Methods:Forty-four healthy right-handed subjects were divided at random into a dominant cerebellum group ( n=15), a non-dominant cerebellum group ( n=15) and a control group ( n=14). In the dominant cerebellum group, iTBS was administered to the cerebellum of the dominant hemisphere, and the other hemisphere was given sham stimulation. In the non-dominant cerebellum group, it was the opposite. The dominant cerebellum received the sham stimulation. In the control group both hemispheres received sham stimulation. Before and after the stimulation, single-pulse transcranial magnetic stimulation (TMS) was applied to the representative regions of suprahyoid muscles in bilateral brain and cerebellum to observe changes of the latency and amplitude of motor evoked potentials (MEPs). Results:After the intervention the MEP amplitude of the bilateral swallowing cortex and the stimulated cerebellum had increased in the non-dominant cerebellum group, with increased MEP amplitude only from the stimulated cerebellum of the dominant cerebellum group. Compared with the control group, the non-dominant cerebellum group showed the greatest improvement in MEP amplitude of the stimulated bilateral cerebral cortex and cerebellum. Improvement in the dominant cerebellum group was significantly smaller. However, there were no significant differences in MEP latency or the percentage change in MEP latency from baseline among the three groups.Conclusions:Applying iTBS to either the non-dominant or the dominant cerebellum excites the brain areas related to swallowing, but in different ways.
