Supplementing rehabilitation training with botulinum neurotoxin improves outcomes for Parkinson′s disease patients with striatal foot deformity
10.3760/cma.j.issn.0254-1424.2023.02.012
- VernacularTitle:肉毒毒素联合康复训练治疗帕金森病患者纹状体足畸形的疗效观察
- Author:
Xue LI
1
;
Liuyi LI
;
Shucheng XING
;
Siyuan CHEN
;
Shaopu WU
;
Qi GU
;
Dongsheng LI
;
Jianjun MA
Author Information
1. 郑州大学人民医院（河南省人民医院，河南大学人民医院）神经内科，郑州 450003
- Keywords:
Parkinson′s disease;
Striatal foot deformity;
Botulinum toxin type A;
Rehabilitation training
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2023;45(2):146-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe any therapeutic effect of combining botulinum toxin type A (BTX-A) with rehabilitation training in treating Parkinson′s disease (PD) patients with striatal foot deformity (SFD).Methods:A total of 68 PD patients with SFD were randomly divided into a control group and a treatment group. Both groups were given routine medication with pramipexole and dopamine receptor agonists and received lower limb rehabilitation training, including passive activity training, strength training and walking training. The treatment group was additionally injected with BTX-A. Sciatic pain was quantified using a visual analogue scale. The Unified Parkinson′s Disease Rating Scale-lower limb motor lower limb motor function (UPDRS-LLM) scale, the Berg balance scale and the modified Barthel index were applied to test all of the participants before the experiment and on the 7th, 14th and 30th day of the treatment.Results:The average scores of the control group on all of measures at were significantly better than those of the control group at the same time points, and by the 14th and 30th day had improved significantly compared with those before treatment.Conclusion:Supplementing rehabilitation training with BTX-A can significantly improve foot deformity and relieve the muscle tension and spastic pain of PD patients with SFD, promoting the motor functioning of their lower limbs, their balance and their performance in the activities of daily living.
