Neuroprotection and potential mechanism of xenon on neonatal hypoxic-ischemic encephalopathy
10.3760/cma.j.cn113903-20220914-00822
- VernacularTitle:氙气对新生儿缺氧缺血性脑病的神经保护作用及其可能机制
- Author:
Mengya SUN
1
;
Ting LI
;
Hong JIANG
Author Information
1. 青岛大学附属医院新生儿科，青岛 266000
- Keywords:
Xenon;
Hypoxia-ischemia, brain;
Neuroprotection;
Infant, newborn
- From:
Chinese Journal of Perinatal Medicine
2023;26(4):339-343
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal hypoxic-ischemic encephalopathy often causes long-term adverse effect on neurological system or even death in near-term or full-term infants, but no effective treatment is available currently. Studies have shown that xenon can reduce brain injury caused by hypoxia-ischemia and is promising in clinical practice. The possible mechanisms include antagonism to glutamic acid receptors, anti-apoptosis, promotion of cell repair and xenon preconditioning. This article reviews the mechanism and research progress on neuroprotection effect of xenon in the treatment of neonatal hypoxic-ischemic encephalopathy.
