Effect of materal anti-Sj?gren's syndrome type A/Sj?gren's syndrome type B antibodies on fetal heart development and the management
10.3760/cma.j.cn113903-20220719-00722
- VernacularTitle:抗干燥综合征抗原A和抗干燥综合征抗原B抗体对胎儿心脏的影响及诊断治疗
- Author:
Mengying ZHANG
1
;
Lihong ZHAI
;
Xiao SUN
Author Information
1. 北京大学第一医院妇产科，北京 100034
- Keywords:
Antibodies, antinuclear;
Autoantigens;
Ribonucleoproteins;
Fetal heart;
Heart block;
Heart diseases;
Prenatal diagnosis;
Fetal therapies
- From:
Chinese Journal of Perinatal Medicine
2022;25(12):987-990
- CountryChina
- Language:Chinese
-
Abstract:
Anti-Sj?gren's syndrome type A（SSA) and anti-Sj?gren's syndrome type B（SSB) antibodies both belong to the antinuclear antibody spectrum and are common in patients with systemic lupus erythematosus, Sj?gren's syndrome and undifferentiated connective tissue disease as well as asymptomatic patients. Approximately 1% of pregnant women are positive for anti-SSA and anti-SSB antibodies and only 1%-3% of the fetuses carried by primiparae with anti-SSA and anti-SSB antibodies show immune-mediated cardiac conduction and structural abnormalities. Due to its low incidence and insidious onset, some pregnant women were diagnosed positive for antibodies against SSA and SSB for the first time only due to fetal heart block or structural abnormalities during pregnancy. Domestic and international research on the effects of anti-SSA and anti-SSB antibodies on fetal heart and the prenatal monitoring, diagnosis, intrauterine treatment and prognosis of fetal cardiac abnormalities related to anti-SSA and anti-SSB exposure are reviewed to guide the clinical work of obstetrics.
