Progress in pathogenesis of autoantibody-related congenital heart block
10.3760/cma.j.cn113903-20220408-00341
- VernacularTitle:自身抗体相关性先天性房室传导阻滞发病机制的研究进展
- Author:
Tianhao BAI
1
;
Shasha DUAN
;
Yaxi WANG
;
Yilu SHI
;
Lu ZHANG
;
Haiyue ZHAO
;
Xiaoshan ZHANG
Author Information
1. 内蒙古医科大学第一临床医学院，呼和浩特 010059
- Keywords:
Atrioventricular block;
Autoantibodies;
Apoptosis;
Killer cells, natural;
Human leukocyte antigen
- From:
Chinese Journal of Perinatal Medicine
2022;25(12):983-986
- CountryChina
- Language:Chinese
-
Abstract:
Autoantibody-related congenital heart block (ACHB) is a passively acquired autoimmune disease developing in fetuses after exposuring to maternal anti-Ro/Sj?gren's syndrome type A (SSA) antibody and/or anti-La/SSB antibody transported across the placenta, which contributes to fetal heart conduction system damage and signal conduction block at the atrioventricular node. However, fetal atrioventricular block does not necessarily occur with the presence of maternal autoantibodies, indicating its complex pathogenesis. This review focuses on the theories of calcium channels and apoptosis, the influence of other maternal factors and environmental changes on ACHB and the roles of natural killer cells and human leukocyte antigen in ACHB, aiming to provide reference for further study on the pathogenesis.
