Long-term outcomes and influencing factors of idiopathic nephrotic syndrome in children
10.3760/cma.j.cn441217-20220906-00909
- VernacularTitle:儿童特发性肾病综合征远期预后现状及影响因素
- Author:
Yueling ZHU
1
;
Xue HE
;
Jianbing WANG
;
Binbin YANG
;
Wei LI
;
Fang WU
;
Aimin LIU
;
Haidong FU
;
Jianhua MAO
Author Information
1. 浙江大学医学院附属儿童医院肾内科 国家儿童健康与疾病临床医学研究中心 国家儿童区域医疗中心，杭州 310052
- Keywords:
Nephrotic syndrome;
Child;
Prognosis;
Influencing factors
- From:
Chinese Journal of Nephrology
2023;39(6):473-478
- CountryChina
- Language:Chinese
-
Abstract:
Pediatric idiopathic nephrotic syndrome (INS) is characterized by massive albuminuria, hypoproteinemia, edema and hyperlipidemia, with a long course and high probability of relapse and prolongation. Long-term complications caused by long-term usage of hormones and immunosuppressants in children with INS seriously affect their physical and mental health and quality of life. Most children with steroid-sensitive nephrotic syndrome can be cured before adulthood, while some of them relapse in adulthood. Long-term prognosis of children with steroid-resistant nephrotic syndrome is poor. There have been few studies in China followed the long-term outcomes and its related factors of children with INS over 10 years. The paper reviewed the literatures on the long-term outcomes of children with INS, including renal survival, growth, mental health, learning and work, marriage and fertility, disease recurrence and long-term related complications, to explore the factors related to the poor long-term outcomes of children with INS and to assist in clinical decision-making and follow-up management.
