IgG4-related kidney disease complicated with membranous nephropathy in one patient with multiple metastatic lung malignancies
10.3760/cma.j.cn441217-20220725-00739
- VernacularTitle:肺恶性肿瘤伴多发转移患者发生IgG4相关肾病合并膜性肾病1例
- Author:
Keqing ZHU
1
;
Guangjun LIU
;
Junhao LYU
;
Qin ZHOU
;
Xiaofeng ZHU
;
Jianghua CHEN
;
Fei HAN
Author Information
1. 浙江大学医学院附属第一医院肾脏病中心，浙江大学肾脏病研究所，浙江省肾脏病防治技术研究重点实验室，杭州 310003
- Keywords:
Lung neoplasms;
Neoplasm metastasis;
Immunoglobulin G;
Glomerulonephritis, membranous
- From:
Chinese Journal of Nephrology
2023;39(5):389-392
- CountryChina
- Language:Chinese
-
Abstract:
Here we report the diagnosis and treatment of a rare IgG4-related kidney disease with nephrotic syndrome as the first manifestation. A 62-year-old male patient, presented with edema in both lower limbs and foam urine, had a history of "lung malignant tumor with brain and lymph node metastasis". The increase of IgG4 and decrease of glomerular filtration rate were detected at admission, and the pathological consideration of renal biopsy was membranous nephropathy with IgG4-related tubulointerstitial nephritis. After the combination of low-dose glucocorticoids therapy and rituximab treatment, the patient showed good prognosis in a 9 month follow-up.
