Metabolic regulation of Nod-like receptor protein 3 inflammasome and its role in renal diseases
10.3760/cma.j.cn441217-20220630-00646
- VernacularTitle:Nod样受体蛋白3炎性小体的代谢调控及其在肾脏疾病中的作用
- Author:
Min WANG
1
;
Zhaohui HUANG
;
Yonghong ZHU
;
Xin LI
;
Yue LIU
;
Ping HE
;
Tiankui MA
;
Qiuling FAN
Author Information
1. 中国医科大学附属第一医院肾内科，沈阳 110001
- Keywords:
Glycolysis;
Inflammasomes;
NLR family, pyrin domain-containing 3 protein;
Citric acid cycle;
Metabolism
- From:
Chinese Journal of Nephrology
2023;39(4):305-311
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the development of metabolic reprogramming research, people have changed their understanding of the biological effects of immune cells. Under the stimulation of inflammatory response, immune cells re-regulate their metabolism and bioenergetics, provide energy and substrates for cell survival, and initiate immune effect functions. Nod-like receptor protein 3 (NLRP3) inflammasome, as an important component of the innate immune system, has been shown to sense metabolites such as uric acid and cholesterol crystals, and can be inhibited by metabolites such as ketones. It is also regulated by mitochondrial reactive oxygen species and glycolytic components (such as hexokinase). Recent studies have shown that a variety of metabolic pathways converge as effective regulators of NLRP3 inflammasome. The paper reviews the metabolic regulatory pathways and specificity of NLRP3 inflammasome activation, and its role in renal diseases.
