Advances in the regulation of autosomal dominant polycystic kidney disease by Hippo signaling pathway
10.3760/cma.j.cn441217-20220506-00507
- VernacularTitle:Hippo信号通路调控常染色体显性多囊肾病的研究进展
- Author:
Jieting ZHANG
1
;
Jing XU
;
Cheng XUE
;
Zhiguo MAO
Author Information
1. 上海大学医学院，上海 200444
- Keywords:
Polycystic kidney, autosomal dominant;
Cysts;
Hippo signaling pathway;
Treatment strategy
- From:
Chinese Journal of Nephrology
2023;39(3):224-228
- CountryChina
- Language:Chinese
-
Abstract:
The Hippo signaling pathway is highly conserved in evolution, and participates in the regulation of cell proliferation, differentiation, and tissular dynamic balance, and plays an important role in regulating tissue, organ size, and cell number. Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and one of the most common causes of end-stage renal disease. Emerging studies have identified the Hippo signaling pathway is closely related to the occurrence and development of ADPKD. The abnormal activity and expression of the main members of the pathway affect the cilia and cell polarity of renal tubular epithelial cells and induce the formation of renal cysts. The review summarizes the potential mechanism of the Hippo pathway in the pathogenesis of ADPKD, the crosstalk with other signaling pathways, and the variances in different species, and discusses the strategies for the treatment of ADPKD based on the Hippo signaling pathway to provide new strategies for the treatment.
