Severe COVID-19 complicated with mild encephalitis/encephalopathy with reversible splenial lesion of the corpus callosum: a case report
10.3760/cma.j.cn113694-20230310-00176
- VernacularTitle:重症COVID-19合并轻度脑炎或脑病伴可逆性胼胝体压部病变1例
- Author:
Kang WANG
1
;
Hui ZHAO
;
Xiuzhu ZHENG
;
Fengchao GONG
;
Xiying HE
;
Tong ZHAO
Author Information
1. 山东第一医科大学第二附属医院神经内科，泰安 271000
- Keywords:
SARS-CoV-2;
Corpus callosum;
Cytotoxicity, immunologic;
Pathogenesis
- From:
Chinese Journal of Neurology
2023;56(9):1055-1059
- CountryChina
- Language:Chinese
-
Abstract:
Since the global COVID-19 pandemic, SARS-CoV-2 infection, which causes COVID-19, has been associated with a range of diseases whose atypical manifestations have been increasingly reported. The mild encephalitis or encephalopathy associated with reversible corpus callosum lesions or mild encephalitis/encephalopathy with reversible splenial lesion (MERS) is a rare clinical and radiographic syndrome. At present, the pathogenesis of MERS caused by COVID-19 is still unclear, and its pathogenesis may include hypoxic damage, inflammatory response, immune disorders, changes in osmotic pressure, excitatory amino acid toxicity, oxidative stress and functional abnormalities of renin-angiotensin system. This paper reports a case of severe COVID-19 complicated with MERS, and discusses the pathogenesis from a pathophysiological point of view.
