Advances in molecular imaging of cerebral amyloid angiopathy
10.3760/cma.j.cn113694-20230324-00217
- VernacularTitle:脑淀粉样血管病的分子影像研究进展
- Author:
Yuhui SHA
1
;
Jun NI
Author Information
1. 中国医学科学院北京协和医学院北京协和医院神经科，北京 100730
- Keywords:
Cerebral amyloid angiopathy;
Positron-emission tomography;
Cerebral hemorrhage;
Molecular imaging;
Amyloid-β
- From:
Chinese Journal of Neurology
2023;56(8):932-938
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral amyloid angiopathy (CAA) is a common age-related small vessel disease characterized by amyloid-β (Aβ) deposition in the wall of small arterioles and capillaries of the leptomeninges and cerebral cortex. Several molecular imaging technologies such as amyloid-β positron-emission tomography (PET) and 18F-fluorodeoxyglucose-PET have been successfully applied in the patients with CAA. Amyloid-PET may indicate the distribution and burden of Aβ deposition by the tracer′s specific binding to the pathological markers, providing qualitative and quantitative information for the diagnosis of CAA. However, amyloid-β PET is inadequate to differentiate CAA from other Aβ-related diseases like Alzheimer′s disease. Other novel techniques of molecular imaging including tau-PET, single photon emission computed tomography and other highly selective PET radioligands have been investigated widely at present. This article mainly reviewed the advances in molecular imaging of CAA.
